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作者比较了活动期（ＡＤＵ）、愈合期（ＨＤＵ）及瘢痕期（ＳＤＵ）球溃疡（ＤＵ）患者和非溃疡对照（ＮＵ），患者的基础胃酸分泌量（ＢＡＯ）、高峰胃酸分泌量（ＰＡＯ）及胃窦粘膜内胃泌素（Ｇａｓ）、生长抑素（ＳＳ）、血管活性肠肽（ＶＩＰ）、Ｐ物质（ＳＰ）的含量。发现各期球溃疡患者ＰＡＯ均明显高于ＮＵ组；ＡＤＵ组胃窦粘膜Ｇａｓ及ＳＰ含量比ＮＵ组明显增加；ＳＤＵ组胃窦粘膜内ＳＳ较ＮＵ组明显增加。本文结果说明壁细胞泌酸能力增加是ＤＵ发病的重要病理生理基础，基础胃酸高分泌状态是ＤＵ患者溃疡活动的重要条件。ＡＤＵ患者ＢＡＯ增加与胃窦粘膜内Ｇａｓ增加有关。ＳＤＵ患者胃窦粘膜内ＳＳ有稳定基础胃酸分泌的作用。
The authors compared basic gastric acid secretion (BAO) and peak gastric acid secretion (PAO) in patients with ADU, HDU and DU ulceration (DU) and non-ulcer control (NU) ), Gastric gastrin (Gas), somatostatin (SS), vasoactive intestinal peptide (VIP) and substance P (SP) were measured. The PAO of patients with ulcer in each stage was significantly higher than that of NU group. The contents of Gas and SP in gastric antrum increased significantly in ADU group than those in NU group. The SS in antral mucosa of SDU group was significantly higher than that in NU group. The results of this paper show that increased parietal cells acid secretion is an important pathophysiology of DU pathogenesis, basal acid hypersecretion is an important condition for ulcer activity in DU patients. Increased BAO in patients with ADU is associated with an increase in Gas in the antral mucosa. SS in gastric mucosa of SDU patients have stable basic gastric acid secretion.