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目的评价氨溴索辅助治疗新生儿胎粪吸入综合征的临床疗效。方法将2007年7月至2011年9月河池市第一人民医院儿科收治的羊水胎粪Ⅱ～Ⅲ度感染的58例足月新生儿胎粪吸入综合征患儿随机分为两组,对照组28例给予常规对症、支持治疗,观察组在对照组的基础上加用氨溴索注射液,剂量为7.5 mg/(kg.次),2次/d,连用5～7 d。比较两组患儿症状体征消失时间、氧疗时间、住院天数及临床疗效。结果观察组紫绀消失时间、肺部啰音消失时间、氧疗时间及住院天数均明显短于对照组(P<0.05);观察组总有效率(93.33%)明显高于对照组(82.14%),差异有统计学意义(P<0.05)。结论氨溴索辅助治疗新生儿胎粪吸入综合征能迅速改善患儿临床症状、体征,疗效确切,值得临床应用。
Objective To evaluate the clinical efficacy of ambroxol in the treatment of neonatal meconium aspiration syndrome. Methods From July 2007 to September 2011, Hechi City People’s Hospital pediatric patients with meconium-stained amniotic fluid Ⅱ ~ Ⅲ degree 58 cases of full-term neonatal meconium aspiration syndrome were randomly divided into two groups, control group 28 cases were given conventional symptomatic and supportive treatment. The observation group was treated with ambroxol at a dose of 7.5 mg / (kg) twice a day for 5-7 days. The signs and symptoms disappear time, oxygen therapy time, hospitalization days and clinical curative effect in both groups were compared. Results The disappearance time of cyanosis, the disappearance of pulmonary rales, the duration of oxygen therapy and days of hospital stay in observation group were significantly shorter than those in control group (P <0.05). The total effective rate (93.33%) in observation group was significantly higher than that in control group (82.14%) , The difference was statistically significant (P <0.05). Conclusion Ambroxol adjuvant treatment of neonatal meconium aspiration syndrome can rapidly improve the clinical symptoms, signs and curative effect in children, which is worthy of clinical application.