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新生儿系指出生后一个月以内的婴儿,患病率较高,有些医生使用西药特别慎重,而习惯于应用被认为几乎无副作用的中药进行治疗。然而,不宜使用内含苯甲醇附加剂的中药注射液如鱼腥草、热痛宁、野菊花、板兰根、抗腮腺炎等注射液,这是因为苯甲醇在体内氧化为苯甲酸,在肝中与甘氨酸结合生成马尿酸排除体外,上述反应系酰基结合,常需借助于酰基辅酶A合成酶和酰基转移酶的催化进行的。而新生儿未成熟的肝脏缺乏这些酶,故对苯甲醇代谢能力低,易显示毒性。其临床症状有代谢性酸中毒、中枢抑制、呼吸窘迫乃至喘息性呼吸、血压下降、肾损害、癫病性发作和颅内出血等。
A newborn refers to infants who are born within a month of birth and have a high prevalence. Some doctors use western medicine with particular caution and are accustomed to using traditional Chinese medicine that is considered to have almost no side effects. However, it is not advisable to use traditional Chinese medicine injection containing benzyl alcohol additive such as Houttuynia cordata Thunb, heat pain Ning, wild chrysanthemum, Banlangen, anti-parotid and other injection, which is because benzyl alcohol in the body oxidized to benzoic acid in the liver In combination with the formation of hippuric acid glycine excreted in vitro, the reaction of acyl-binding, often need to aid the acyl-CoA synthetase and acyltransferase catalyzed. Neonatal immature liver lack of these enzymes, it is low on the metabolism of benzyl alcohol, easy to show toxicity. The clinical symptoms of metabolic acidosis, central suppression, respiratory distress and even wheezing, decreased blood pressure, kidney damage, epileptic seizures and intracranial hemorrhage.