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作者用每片含醋炔诺酮(NA)1mg+乙炔雌二醇(EE)0.05mg的口服避孕药(OC)作阴道内给药研究,研究包括20例妇女,年龄20～35岁,具有正常生育能力,参与研究前6个月均有规则月经(周期26～30天),且至少有3个月未用过任何甾体避孕药,随机分成两组,每组10人,第1组每天给药2片,第2组每天给药1片。所有对象用药前先研究1个对照周期,以后在月经第5天开始给药,连续给药21天。计划用药2个周期,由于有些妇女自动要求继续用药,因此有3例用药3个周期,7例用药4个周期,用药周期总数为57个周期,于对照和用药周期第20天和24天取血样,用RIA法作孕酮(P)测定,用Technicon MTII自动分析仪测定血糖、总蛋白、白蛋白和胆固醇浓度,用Lopes-Verella等法测定高密度脂蛋白含量。于每个周期第24天取子宫内膜,按Novak和
The authors used an intravaginal dose of oral contraceptive (OC) containing 0.05 mg of norethindrone acetate (NA) and ethinyl estradiol (EE) 0.05 mg each. The study included 20 women aged 20-35 years with normal Fertility. Regular menstruation (cycle 26-30 days) was observed in the first 6 months of the study, and no steroid contraceptive was used for at least 3 months. Patients were randomly divided into two groups of 10 in each. Group 1 received daily Administered 2 tablets, the second group administered 1 tablet daily. All subjects before the study of a control cycle, after the first five days of menstruation, continuous administration of 21 days. There are 3 cycles of medication 3 cycles, 7 cycles of medication 4 cycles and a total of 57 cycles of medication for some periods of 20 days and 24 days for the control and medication cycles, as some women are automatically required to continue their medication, Blood samples were determined for progesterone (P) by the RIA method. Blood glucose, total protein, albumin and cholesterol concentrations were determined using a Technicon MTII automated analyzer. High-density lipoprotein was measured by the Lopes-Verella method. On the 24th day of each cycle, take the endometrium, press Novak and