肥胖已成为影响我国成人和儿童健康的巨大挑战,我国35~64岁中年人群超重率已达38.8%,肥胖率20.2%~(〔1〕)。Ⅱ型糖尿病、心血管疾病、高血压、骨关节炎以及肿瘤均与肥胖密切相关~(〔2〕)。近年来研究表明,由肿瘤细胞、正常细胞、细胞内基质及相关信号分子等组成的肿瘤微环境在肿瘤的扩散、转移及耐药等方面发挥了重要作用~(〔3〕)。在实体肿瘤中,肿瘤细胞与成纤维细胞、巨噬细胞、淋巴细胞、内皮细胞以及脂肪细胞等相互作用,通过细胞 Obesity has become a huge challenge affecting the health of both adults and children in our country. The overweight rate of 38-45% middle-aged people aged 35-64 years in our country has obesity rate of 20.2% ~ (〔1〕). Type 2 diabetes, cardiovascular disease, hypertension, osteoarthritis, and cancer are closely related to obesity (2). In recent years, studies have shown that the tumor microenvironment composed of tumor cells, normal cells, intracellular matrix and related signaling molecules plays an important role in the spread, metastasis and drug resistance of tumor (3). In solid tumors, tumor cells interact with fibroblasts, macrophages, lymphocytes, endothelial cells, and adipocytes and pass through the cells