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目的:对疑苯二氮类药物(BZDs)过量患者测定其血BZDs浓度,确定药物过量与BZDs浓度的关系。方法:对急诊疑BZDs药物过量病人104例,采用荧光偏振免疫法测定血BZDs浓度。结果:104例药物过量病人血BZDs药物呈阳性,浓度高低不一。浓度低于100Ong/ml的病人其预后明显好于浓度超过1000ng/ml的病人。结论:采用该法测定BZDs药物血药浓度对临床及时诊断和治疗有一定参考价值,但要注意测定结果并不能代表临床病情的轻重。
OBJECTIVE: To determine the concentration of BZDs in patients with suspected excess of benzodiazepines (BZDs) and determine the relationship between drug overdose and the concentration of BZDs. Methods: 104 cases of patients suspected of overdose of suspected BZDs were randomly divided into two groups. Fluorescence polarization immunoassay was used to measure blood BZDs concentration. Results: 104 cases of drug overdose patients with blood BZDs drug-positive, varying in concentration. Patients with concentrations below 100 Ong / ml have significantly better outcomes than those with concentrations exceeding 1000 ng / ml. Conclusion: The determination of blood concentration of BZDs by this method has certain reference value for clinical diagnosis and treatment in time. However, it should be noted that the determination results do not represent the severity of clinical conditions.