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[目的]探讨生长激素释放肽(Ghrelin)在非小细胞肺癌组织中的表达及其临床意义。[方法]应用免疫组织化学法检测72例肺癌组织及30例肺正常组织中Ghrelin的表达,分析非小细胞肺癌不同临床病理特征组Ghrelin的表达差异。[结果]在肺癌组织中Ghrelin阳性率为58.33%,显著高于正常肺组织的13.33%(P<0.05);Ghrelin表达与患者性别、吸烟、分化程度、病理类型均无相关性(P>0.05),与临床分期、淋巴结转移有关(P<0.05)。[结论]非小细胞肺癌组织中Ghrelin过度表达,可能对肺癌的发生发展及侵袭转移起着一定的作用。
[Objective] To investigate the expression of ghrelin in non-small cell lung cancer and its clinical significance. [Method] The expression of Ghrelin in 72 cases of lung cancer and 30 cases of normal lung tissues was detected by immunohistochemistry. The expression of Ghrelin in different clinicopathological features of non-small cell lung cancer was analyzed. [Results] The positive rate of Ghrelin in lung cancer was 58.33%, significantly higher than that in normal lung (13.33%, P <0.05). There was no correlation between Ghrelin expression and gender, smoking, differentiation and pathological type (P> 0.05 ), And clinical stage, lymph node metastasis (P <0.05). [Conclusion] Overexpression of Ghrelin in non-small cell lung cancer may play a role in the development, invasion and metastasis of lung cancer.