角膜新生淋巴管(CL)存在于血管化角膜上,常引起并加重角膜混浊和角膜移植排斥反应,是重要的致盲原因之一。血管内皮生长因子C(VEGF-C)是血管内皮生长因子(VEGF)家族成员之一,是VEGFR-2和VEGFR-3受体的配体。VEGF-C通过与VEGFR-3结合促进淋巴管增生,是一个特异性的淋巴管生长因子,在CL形成中起着重要的作用。就近年来CL研究进展及与VEGF-C的关系进行综述。 Corneal neovascularization (CL), which is present on the vascularized cornea, often causes and worsens corneal opacity and corneal graft rejection and is one of the important causes of blindness. Vascular endothelial growth factor C (VEGF-C) is a member of the vascular endothelial growth factor (VEGF) family and is a ligand for VEGFR-2 and VEGFR-3 receptors. VEGF-C promotes lymphangiogenesis by binding to VEGFR-3 and is a specific lymphangiogenic growth factor that plays an important role in CL formation. In recent years, CL research progress and its relationship with VEGF-C are reviewed.