4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pa

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AIM: Activated pancreatic stellate cells (PSCs) are implicated in the pathogenesis of pancreatic inflammation and fibrosis,where oxidative stress is thought to play a key role. 4-hydroxy-2,3-nonenal (HNE) is generated endogenously during the process of li
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