Fast reactors based on thorium fuel have enhanced inherent safety.Fluoride salt performs well as a coolant in high-temperature nuclear systems.In this paper,we present a reference core for a large fluoride-salt-cooled solid-fuel fast reactor (LSFR) using thorium-uranium fuel cycle.Neutronics physics of the LSFR reference core is investigated with 2D and 3D in-core fuel management strategy.The design parameters analyzed include the fuel volume fraction,power density level and continuous removal of fission products with 3D fuel shuffling that obtains better equilibrium core performance than 2D shuffling.A self-sustained core is achieved for all cases,and the core of 60％ fuel volume fraction at 50 MW/m3 power density is of the best breeding performance (average breeding ratio 1.134).The LSFR core based on thorium fuel is advantageous in its high discharge bu-up of 20-30％ fissions per initial heavy metal atom,small reactivity swing over the whole lifetime (to simplify the reactivity control system),the negative reactivity temperature coefficient (intrinsically safe for all cases) and accepted cladding peak radiation damage.The LSFR reactor is a good alteative option for the deployment of a self-sustained thorium-based nuclear system.