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咽旁间隙解剖结构复杂、肿瘤病理类型繁多，临床表现各异。因此，咽旁间隙肿瘤的诊断和治疗皆较头颈部其他肿瘤困难。双合诊、影像学检查、细针穿刺细胞学、经口或经颈活检等综合诊断方法，可判定肿瘤性质、血液供给，了解肿瘤与周围重要组织的关系，为制定治疗方案提供可靠依据。就咽旁间隙肿瘤的临床诊断及治疗，尤其是手术径路的选择作了综述。“,”Anatomy of parapharyneal space is very complicated.Many types of parapharyngeal space neoplasms can occur,and all of them demonstrate different clinical manifestations.Therefore,it is more difficult to diagnose and treat the parapharyngeal space neoplasms than other head and neck neoplasms.Common diagnostics methods include bimanu-al examination,imaging studies,cytopathology,transoral and transcervical biopsy.All these methods can help doctor determine the nature and blood supply of tumors and understand the relationship between neoplasms and adjacent struc-ture,which provide a reliable basis for the ensuing treatment.This paper aims to state the diagnosis and treatment of parapharyngeal space neoplasms,especially how to select surgical procedures.