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目的探讨C-MET蛋白在甲状腺乳头状癌中的表达对甲状腺癌有无颈淋巴结转移的预测价值。方法采用术中快速免疫组化法检测85例甲状腺乳头状癌的C-MET表达,以期了解颈部淋巴结的转移情况。所有患者均行颈部淋巴结功能性清扫,比较C-MET蛋白两种染色强度的淋巴结转移率。结果染色强阳性25例,染色阳性60例。染色强阳性组淋巴结转移率明显高于染色阳性组(P<0.001)。结论 C-MET的表达是甲状腺乳头状癌是否有淋巴结转移的预测因子。术中快速免疫组化检查对决定是否行淋巴结清扫有一定的指导意义。
Objective To investigate the predictive value of C-MET protein expression in papillary thyroid carcinoma for cervical lymph node metastasis. Methods Expressions of C-MET in 85 cases of thyroid papillary carcinoma were detected by rapid immunohistochemistry in order to understand the metastasis of cervical lymph nodes. All patients underwent functional cervical lymph node dissection, comparing the staining intensity of C-MET protein lymph node metastasis. Results strong staining in 25 cases, 60 cases of positive stain. The strong positive staining of lymph node metastasis rate was significantly higher than the positive staining group (P <0.001). Conclusion The expression of C-MET is a predictor of thyroid papillary carcinoma with lymph node metastasis. Intraoperative rapid immunohistochemical examination of the lymph node dissection to determine whether there is a guiding significance.