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目的对广州地区女性下生殖道感染致病微生物状况进行调查,用以指导临床正确诊断治疗。方法对以外阴瘙痒及白带增多为主诉的妇女患者进行临床检查,先取阴道分泌物进行pH、胺试验及假丝酵母菌、滴虫和线索细胞检查,同时采用特制密封棉拭子宫颈管内取样,然后采用重量差减法,求出分泌物的重量,采用荧光定量PCR测定解脲脲原体、淋球菌、沙眼衣原体,可疑部位取材作HSV和HPV检测及梅毒血清学检查。结果在533例入选患者中,解脲脲原体感染345例占64.7%,沙眼衣原体感染142例占26.6%,阴道假丝酵母菌病117例占22%,非特异性阴道炎81例占15%,细菌性阴道病17例占0.03%。尖锐湿疣12例占0.02%。淋病5例,梅毒4例,生殖器疱疹2例,滴虫阴道炎2例。结论解脲脲原体、沙眼衣原体、阴道假丝酵母菌病是当前广州地区女性下生殖道感染的主要致病微生物,在选用抗生素时要兼顾解脲脲原体、沙眼衣原体。
Objective To investigate the prevalence of pathogenic microorganisms in lower genital tract infections in women in Guangzhou to guide clinical diagnosis and treatment. Methods The patients with genital pruritus and leucorrhoea increased mainly for clinical examination. The vaginal secretions were taken for pH, amine test and candida, trichomoniasis and clue cell examination. Cervical tube sampling was performed with a special sealed cotton swab. Then using the weight subtraction method, the weight of the secretions was obtained. Ureaplasma urealyticum, Neisseria gonorrhoeae and Chlamydia trachomatis were determined by fluorescence quantitative PCR. The suspicious sites were taken for HSV and HPV testing and syphilis serological tests. Results Of the 533 patients enrolled, 345 (64.7%) were Ureaplasma urealyticum, 142 (26.6%) were Chlamydia trachomatis, 117 (22%) were Candida vaginitis, 81 (15%) were Non-specific vaginitis , 17 cases of bacterial vaginosis accounted for 0.03%. 12 cases of genital warts accounted for 0.02%. 5 cases of gonorrhea, 4 cases of syphilis, 2 cases of genital herpes, 2 cases of trichomoniasis vaginitis. Conclusion Ureaplasma urealyticum, Chlamydia trachomatis and Candida vaginitis are the main pathogenic microorganisms in lower genital tract infections in women in Guangzhou. In the selection of antibiotics, both Ureaplasma urealyticum and Chlamydia trachomatis should be considered.