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目的:观察A型性格、性激素水平在原发性青光眼发病过程中的相互关系及临床意义。方法:采用病例对照研究的方法,对75例绝经后女性(原发性青光眼组、老年性白内障对照组及正常对照组,每组各25例)进行性格类型评定,并采用电化学发光免疫法检测各实验对象血清及房水性激素:雌二醇(E2)、孕酮(P)睾酮(T)。结果:(1)青光眼组A型性格所占百分率明显高于白内障组及正常对照组。(2)绝经后女性原发性青光眼患者普遍存在性激素失衡,其中A型性格患者更为显著。血清E2水平较正常对照组降低(P<0.05),房水E2水平较白内障对照组明显降低(P<0.01)。(3)青光眼组性格类型问卷评分与血清和房水E2水平呈负相关。结论:A型性格是青光眼的易患模式。A型性格者易发生体内E2失衡。体内E2水平与青光眼的发生密切相关。
Objective: To observe the relationship between type A personality and sex hormone levels in the pathogenesis of primary glaucoma and its clinical significance. Methods: A case-control study was conducted in 75 postmenopausal women (primary glaucoma group, senile cataract control group and normal control group, 25 cases in each group) for personality type assessment. Electrochemiluminescence immunoassay Serum and aqueous humor hormones were detected in each subject: estradiol (E2) and progesterone (P) testosterone (T). Results: (1) The percentage of type A personality in glaucoma group was significantly higher than that in cataract group and normal control group. (2) The prevalence of sex hormone imbalance in postmenopausal women with primary glaucoma, of which type A personality is more significant. Serum E2 level was lower than that of normal control group (P <0.05), E2 level of aqueous humor was significantly lower than that of cataract control group (P <0.01). (3) The glaucoma group’s personality type questionnaire score was negatively correlated with E2 level of serum and aqueous humor. Conclusion: Type A personality is a predisposing pattern to glaucoma. Type A personality prone to E2 imbalance in the body. E2 levels in vivo and the occurrence of glaucoma are closely related.