论文部分内容阅读
目的:研究了异烟肼(Isoniazid,INH)在10-甲基吩噻嗪修饰碳糊电极(10-methylphenothiazine modified carbon paste e-lectrode,MPT/CPE)上的电化学行为和电化学分析方法。方法:循环伏安法(Cyclic voltammetry,CV)、计时电流法(Chrono-amperometry,CA)和方波伏安法(Squarewa vevoltammetry,SWV)。结果:INH在碳糊电极(Carbon paste electrode,CPE)上的直接电化学氧化过程十分迟缓,MPT/CPE对INH电化学氧化具有良好的催化作用。同时测定了INH在MPT/CPE上的电极过程动力学参数,用方波伏安法(SWV)测得催化氧化峰电流与INH在5.0×10-7～1.0×10-4mol.L-1浓度范围内呈良好线性关系,线性回归方程为Ipa(μA)=186.63C(10-3mol.L-1)+30.30,r=0.9971,检出限为2.1×10-7mol.L-1(S/N=3)。结论:本方法灵敏度高,操作简单,可用于INH电化学定量测定。
OBJECTIVE: To study the electrochemical behavior and electrochemical analysis of isoniazid (INH) on 10-methylphenothiazine modified carbon paste e-lectrode (MPT / CPE). Methods: Cyclic voltammetry (CV), chronoamperometry (CA) and square wave voltammetry (SWV) were performed. Results: The direct electrochemical oxidation of INH on carbon paste electrode (CPE) was very slow. MPT / CPE had a good catalytic effect on the electrochemical oxidation of INH. The electrode kinetic parameters of INH on MPT / CPE were also measured. The oxidation peak current and the INH of 5.0 × 10-7 ~ 1.0 × 10-4mol.L-1 measured by the square wave voltammetry (SWV) The linear regression equation was Ipa (μA) = 186.63C (10-3mol.L-1) + 30.30, r = 0.9971 with a detection limit of 2.1 × 10-7mol.L-1 (S / N = 3). Conclusion: The method is sensitive and easy to operate and can be used for INH electrochemical quantitative determination.