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采用５月龄Ｗｉｓｔａｒ大鼠，用ＣＣＬ４灌胃致大鼠形成肝组织纤维化，并试以慈菇作为ＣＣＬ４致大鼠肝纤维化过程的干预因素的实验。结果显示：在肝纤维化发生的同时，血清ＮＯ、ＴＮＦ－α显著增多，腹腔巨噬细胞诱生的ＮＯ、ＴＮＦ－α也明显增多；在实验的第８～１２周，灌饲慈菇汁的大鼠血清及腹腔巨噬细胞诱生的ＮＯ、ＴＮＦ－α水平均明显低于阳性对照组。提示ＮＯ和ＦＮＦ－α在肝纤维化过程中起重要作用，慈菇可减轻ＣＣＬ４致大鼠肝纤化程度并减少ＮＯ与ＴＮＦ－α的产生。
Using 5-month-old Wistar rats, rats were intragastrically injected with CCL4 to induce hepatic fibrosis, and Sagittiva was used as an intervening factor in the process of hepatic fibrosis induced by CCL4. The results showed that while liver fibrosis occurred, serum NO and TNF-α were significantly increased, and NO and TNF-α induced by peritoneal macrophages were also significantly increased. In the 8th to 12th weeks of experiment, the mushroom juice was fed. The level of NO and TNF-α induced by rat serum and peritoneal macrophages was significantly lower than that of the positive control group. It is suggested that NO and FNF-α play an important role in the process of hepatic fibrosis. Sagittaria can reduce the degree of hepatic fibrosis and reduce the production of NO and TNF-α in rats induced by CCL4.