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目的探讨鼻过敏与鼻窦炎发病的关系。 方法采用手工检索与Internet检索相结合的方法,追踪近年来有关的文献,分析12篇相关文献。结果鼻窦炎为临床常见病,鼻过敏作为鼻窦炎的诱发因素,已经引起重视,但针对鼻过敏反应“各个击破”(在不同环节进行药物干预)的治疗策略,在鼻过敏性疾病常得不到预期效果,因而也不易缓解以鼻过敏为诱发因素的鼻窦炎的症状。虽然MHC系统、Th1/Th2平衡以及细 胞因子网络等是鼻过敏发病的重要基础,但从单种细胞的基因水平分析,肥大细胞可能是Ⅰ型变态反应中最关键的细胞之一;肥大细胞是启动并维持鼻过敏反应的源动性细胞。结论鼻过敏乃至以鼻过敏为诱发因素的鼻窦炎的治疗首先应针对肥大细胞,而非仅限于针对单一细胞因子或抗体。
Objective To investigate the relationship between nasal allergy and sinusitis. Methods The manual retrieval method combined with Internet retrieval was used to trace the related literature in recent years and analyze 12 related literatures. Results Sinusitis is a common clinical disease. Nasal allergy has been paid much attention as an inducing factor of sinusitis. However, in the treatment of nasal allergic reactions, “all breakups” (drug intervention in different aspects), nasal allergic diseases are often not treated To the desired effect, and therefore not easy to alleviate the nasal allergy as a predisposing factor sinusitis symptoms. Although MHC system, Th1 / Th2 balance and cytokine network are the important basis for the pathogenesis of nasal allergy, mast cells may be one of the most critical cells in type Ⅰ allergy, according to the gene level analysis of individual cells. Mast cells are Activated and activated nasal allergic cells. Conclusion Nasal allergy and even nasal allergy-induced sinusitis treatment should first be targeted at mast cells, rather than confined to a single cytokine or antibody.