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【目的】探讨肥胖儿童肾脏损害,为早期干预提供理论依据。【方法】对32例肥胖儿童行尿α1-微球蛋白(α1-M)、微量白蛋白(m-Alb)、免疫球蛋白G(IgG)检测,并以20例健康儿童作为对照。同时检测尿常规、血尿素氮、肌酐、甘油三脂、胆固醇、血糖等。【结果】32例肥胖儿童尿四联蛋白虽然均在正常范围,但与正常对照组比较,除α1-M与正常组比较无显著差异外,其它各指标差异均有统计学意义(P均<0.05)。血尿素氮、肌酐、血糖均在正常范围,与正常组比较差异均无统计学意义(P均>0.05),但血甘油三脂、胆固醇与正常对照组比较均显著增高,差异均有统计学意义(P均<0.05)。【结论】肥胖儿童存在肾功能损害。尿微量蛋白作为早期发现肾脏损害的敏感指标可进一步探讨。
【Objective】 To investigate the kidney damage in obese children and provide a theoretical basis for early intervention. 【Methods】 Urine α1-M, m-Alb and IgG were detected in 32 obese children and 20 healthy children were used as controls. At the same time testing urine, blood urea nitrogen, creatinine, triglycerides, cholesterol, blood sugar and so on. 【Results】 All the 32 cases of obese children with urinary tetrad protein were in the normal range, but there was no significant difference between the two groups except the α1-M and the normal group (P < 0.05). Blood urea nitrogen, creatinine, blood glucose were in the normal range, compared with the normal group was no significant difference (P all> 0.05), but triglyceride, cholesterol and normal control group were significantly higher, the difference was statistically Significance (P <0.05). 【Conclusion】 Obese children have renal dysfunction. Urinary trace protein as a sensitive indicator of early detection of kidney damage can be further explored.