论文部分内容阅读
将交联聚维酮、低黏度羟丙甲纤维素、微晶纤维素、难溶性微粉化药物(如伊曲康唑)和水混合均匀,再用挤出/滚圆技术制备口服多颗粒给药系统。为改善该系统的释药性能,采用以下方法将微米级药物粉末进一步纳米化。先将微米级药物混悬在含有Tween-20的水中,再用高压均质法制成含有纳米级药物颗粒的混悬液,然后喷雾干燥得到纳米级药物。如此处理
The cross-linked povidone, low viscosity hypromellose, microcrystalline cellulose, insoluble micronized drugs (such as itraconazole) and water mixed evenly, and then extrusion / spheronization preparation oral multiparticulate drug delivery system. In order to improve the drug release performance of the system, the following method is used to further micronize the micron-sized drug powder. First micron-sized drug is suspended in water containing Tween-20, and then prepared by high-pressure homogenization method containing a suspension of nano-drug particles, and then spray-dried to obtain nano-level drugs. So deal with it