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患者,女,17岁。2000年10月因疲乏、反复鼻出血就诊,查体:肝肋缘下3cm,脾肿大:AB 线4cm,AC 线5cm,DE 线5.5cm。血常规检查:WBC 179×10~9/L,Hb 102g/L,BPC 917×10~9/L。骨髓检查结果为慢性粒细胞白血病(CML)慢性期。骨髓荧光原位杂交(FISH)检查示 bcr/abl融合基因阳性(95%)。羟基脲诱导缓解后予以 IFN-α治疗(300万 U 皮下注射,隔日1次),其间多次 FISH 复查 bcr/abl融合基因均为阳性(90%～100%)。2005年5月将 IFN-α
Patient, female, 17 years old. October 2000 due to fatigue, repeated nosebleeds treatment, physical examination: liver ribs under 3cm, splenomegaly: AB line 4cm, AC line 5cm, DE line 5.5cm. Blood tests: WBC 179 × 10 ~ 9 / L, Hb 102g / L, BPC 917 × 10 ~ 9 / L. Bone marrow examination results in chronic phase of chronic myeloid leukemia (CML). Bone marrow fluorescence in situ hybridization (FISH) showed positive bcr / abl fusion gene (95%). IFN-α was treated with hydroxyurea (3 million U subcutaneously every other day) after induction of remission, during which time the bcr / abl fusion gene was positive (90% -100%) after repeated FISH. May 2005 will IFN-α