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目的 观察N_(14)是否有致胃肠溃疡作用。方法 对正常大鼠进行连续ig给药7d,每日1次,并与阿司匹林、吲哚美辛进行对照,剂量分别为N_(14)25、50、100mg/kg,阿司匹林25、50、100mg/kg,吲哚美辛1.25、2.5、5mg/kg。结果 N_(14)组与溶媒对照组的结果相近,在发挥主要药效学的剂量下,各大鼠均无明显胃肠溃疡发生,阿司匹林有明显致胃溃疡作用(P<0.05),吲哚美辛有非常明显的致胃溃疡作用(P<0.01)。结论 N_(14)对胃肠道无致溃疡作用,为进一步研究该药提供实验数据。
Objective To observe whether N_ (14) causes gastrointestinal ulcer. Methods Normal rats were administered with ig for 7 days, once a day, with aspirin and indomethacin at doses of 25, 50 and 100 mg / kg, aspirin 25, 50 and 100 mg / kg, indomethacin 1.25, 2.5, 5 mg / kg. Results The results of N_ (14) group were similar to those of vehicle control group. No significant gastrointestinal ulcer occurred in all rats at the dose of main pharmacodynamics, aspirin had obvious effect on gastric ulcer (P <0.05), indole Meixin has a very significant role in causing gastric ulcer (P <0.01). Conclusion N_ (14) has no effect on gastrointestinal tract and provides experimental data for further study of this drug.