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目的探讨原发性高血压病合并2型糖尿病患者动态血压昼夜节律的变化及其意义。方法选取76例原发性高血压病患者按有无糖尿病将其分为两组,A组为原发性高血压病合并2型糖尿病组(40例),B组为原发性高血压病组(36例),分别进行24h动态血压监测。结果A组患者夜间收缩压明显增高(P<0.01),其血压昼夜差值、节律变化与B组比较,差异有显著性意义(P<0.05)。结论原发性高血压病合并2型糖尿病患者夜间血压下降幅度较单纯原发性高血压病患者明显减少,且绝大多数表现为血压昼夜节律异常,提示高血压合并糖尿病患者更易出现靶器官损害,对其进行早期干预,改善体内糖代谢状况,可延缓靶器官并发症的发生和发展。
Objective To investigate the changes and their significance of ambulatory blood pressure circadian rhythm in patients with essential hypertension and type 2 diabetes mellitus. Methods 76 patients with essential hypertension were divided into two groups according to whether there was diabetes mellitus, group A was essential hypertension complicated by type 2 diabetes mellitus (40 cases), group B was essential hypertension Group (36 cases), 24h ambulatory blood pressure monitoring. Results In group A, the systolic pressure at night was significantly higher (P <0.01). The difference of daytime and nighttime blood pressure and rhythm in group A was significantly different from that in group B (P <0.05). Conclusions The decrease rate of nocturnal blood pressure in patients with essential hypertension complicated with type 2 diabetes is significantly lower than that of patients with simple essential hypertension and most of them show abnormal circadian rhythm of blood pressure, suggesting that target organ damage is more likely to occur in hypertensive patients with type 2 diabetes , Its early intervention to improve the status of glucose metabolism in vivo, can delay the occurrence and development of target organ complications.