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目的分析艾滋病病毒(HIV)感染者和艾滋病(AIDS)病人(简称HIV/AIDS病人)合并感染乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)的流行现状及其特点,为AIDS的防控和治疗提供科学依据。方法选取2011-2015年期间准备开始高效抗反转录病毒治疗(HAART)的HIV/AIDS病人986例,采用酶联免疫吸附试验检测HIV/AIDS病人血液中的乙型肝炎表面抗原(HBsAg)和/或丙型肝炎病毒抗体(HCV-Ab)。计数资料样本率的比较采用χ2检验,计量资料的比较采用t检验。结果 HIV/AIDS病人合并HBV感染率为6.06%(59/974),合并HCV感染率为4.12%(40/972),合并HBV/HCV双重感染率为0.42%(4/960),HIV/AIDS病人合并HBV和HCV感染率的差异无统计学意义。血液途径感染HIV者的合并HBV感染率为15.79%,合并HCV感染率为41.03%,均显著高于性途径合并HBV和HCV的感染率(5.01%和1.68%)。合并乙型肝炎病人的CD4+T淋巴细胞<200个/μL的比例,明显高于合并丙型肝炎病人CD4+T淋巴细胞<200个/μL的比例。合并HBV和HCV感染的病人的天冬氨酸转氨酶、丙氨酸转氨酶、总胆红素均没有显著性差异。结论郑州市HIV/AIDS病人合并HBV和HCV总体感染率低于普通人群,HIV合并HBV/HCV感染的趋势有所控制。但血液途径感染HIV者合并HBV和HCV感染率仍高于普通人群,要加大防控力度。
Objective To analyze the prevalence and characteristics of hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infected with HIV-infected and AIDS patients (HIV / AIDS patients) Control and treatment to provide a scientific basis. Methods A total of 986 HIV / AIDS patients were enrolled in HAART during 2011-2015. Enzyme-linked immunosorbent assay (ELISA) was used to detect hepatitis B surface antigen (HBsAg) in blood of HIV / AIDS patients and / Or Hepatitis C virus antibody (HCV-Ab). Count data sample rate comparison using χ2 test, measurement data were compared using t test. Results The prevalence of HBV infection in HIV / AIDS patients was 6.06% (59/974), the combined infection rate was 4.12% (40/972), the combined HBV / HCV infection rate was 0.42% (4/960), HIV / AIDS There was no significant difference in the rates of HBV and HCV co-infection among patients. The combined HBV infection rate of blood infected with HIV was 15.79%, and the combined infection rate of HCV was 41.03%, which were significantly higher than those infected with HBV and HCV (5.01% and 1.68%). The proportion of CD4 + T lymphocytes <200 cells / μL in patients with hepatitis B was significantly higher than that of patients with hepatitis C with CD4 + T lymphocytes <200 cells / μL. There was no significant difference in aspartate transaminase, alanine aminotransferase, total bilirubin in patients with HBV and HCV infection. Conclusion The overall infection rate of HBV and HCV in HIV / AIDS patients in Zhengzhou is lower than that in the general population. The trend of HIV / HCV infection is controlled. However, the blood-infected HIV-infected patients with HBV and HCV infection rates are still higher than the general population, to increase prevention and control efforts.