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目的了解同卵双胎儿与同性别异卵双胎儿超声骨密度值(speed of sound,SOS值)同一性的差异,为人骨密度与基因的相关性提供依据。方法将2010-2013年来我科做正常体检保健的双胎儿按同卵双胎儿、同性别异卵双胎儿分为两组,同卵双胎儿59对,同性别异卵双胎儿78对。分别对2组小儿做骨密度检测,并对2组间SOS差值的差异进行统计学分析。结果同卵双胎儿的SOS值差较同性别异卵双胎儿SOS值差小(P=0.0029)。同异卵两组SOS差值散点图差异的比较显示,同性别异卵组差值分散度明显大于同卵组(P=0.0026)。结论同卵双胎儿的骨密度值更接近,而同性别异卵双胎儿间骨密度值差异较大,提示人的骨密度值与基因相关。
Objective To understand the difference of the SOS value between identical fetus and same-sex fetus, and to provide basis for the correlation between human bone mineral density and gene. Methods From 2010 to 2013, our department did normal pregnancy health check-ups for twins as identical twins and same-sex twins as 59 pairs of identical twins and 78 pairs of identical twins. Bone mineral density (BMD) was measured in two groups of children, and the differences of SOS difference between the two groups were statistically analyzed. Results The SOS value of identical fetus was significantly lower than that of same-sex fetus (P = 0.0029). The comparison of scatter plot of SOS difference between the two groups showed that the dispersion of difference between the same sex and different group was significantly greater than that of the same group (P = 0.0026). Conclusion The BMD of two identical fetuses is closer to each other, while the difference of BMD between two fetuses of the same sex is quite different, suggesting that the BMD of human is related to the gene.