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目的探讨硫普罗宁治疗慢性乙肝患者的临床效果。方法对我院诊断、治疗的80例慢性肝炎患者病历资料进行分析,将患者根据治疗时间顺序分为观察组和对照组。对照组采用常规方法治疗,观察组采用硫普罗宁治疗,比较两组治疗效果。结果观察组70%治疗有效,高于对照组50%(P<0.05);观察组80%对治疗比较满意,高于对照组(P<0.05);观察组治疗(28.0±7.2)d后症状明显改善出院,短于对照组(P<0.05);观察组治疗后ALT指标为(61.5±5.4)、AST指标为(74.6±5.4)、γ-GT指标为(123.8±14.7)、HBV-DNA阳性比例为(20.0%)、HBeAg阳性比例为(8.3%)、优于对照组(P<0.05)。结论慢性乙肝是临床上常见的慢性疾病,临床上采用硫普罗宁治疗效果较好,值得推广使用。
Objective To investigate the clinical effect of tiopronin in the treatment of chronic hepatitis B patients. Methods The data of 80 chronic hepatitis patients diagnosed and treated in our hospital were analyzed. The patients were divided into observation group and control group according to the order of treatment time. The control group was treated by conventional method. The observation group was treated with tiopronin, and the treatment effect was compared between the two groups. Results The observation group was 70% effective, which was 50% higher than that of the control group (P <0.05). 80% of the observation group was more satisfied with the treatment than the control group (P <0.05) (P <0.05); ALT index (61.5 ± 5.4), AST index (74.6 ± 5.4), γ-GT index (123.8 ± 14.7), HBV-DNA The positive rate was (20.0%) and the positive rate of HBeAg was (8.3%), which was better than that of the control group (P <0.05). Conclusion Chronic hepatitis B is a common clinical chronic disease. It is better to use tiopronin in clinical practice, which is worth promoting.