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应用放射免疫分析检测494例e系统阳性慢性乙肝病人血清中乙肝核心抗原(HBcAg)。结果显示HBeAg阳性病人HBcAg检出率为86.1%,抗-HBe阳性病人HBcAg检出率为47.1%,两者有显著性差异(P<0.01);若结合其它血清学标志,在不同血清学标志组合模式下比较:模式Ⅰ(HBsAg、抗-HBc和HBeAg同时阳性)的HBcAg检出率为85.6%,模式Ⅱ(HBsAg、抗-HBc和抗-HBe同时阳性)的HBeAg检出率为90.1%,两者无显著性差异(P>0.05)。提示既往认为HBeAg转变为抗-HBe作为病毒复制停止、病情缓解的指标是不确切的。从血清学角度判断病毒复制及传染性时应从整体出发,不单以某一系统为依据。
Radioimmunoassay was used to detect serum HBcAg in 494 patients with e-positive chronic hepatitis B patients. The results showed that HBeAg positive patients HBeAg positive rate was 86.1%, anti-HBe positive patients HBcAg positive rate was 47.1%, a significant difference between the two (P <0.01); if combined with other serological markers in different serological markers In combination mode, the detection rate of HBcAg was 85.6% in mode Ⅰ (HBsAg, anti-HBc and HBeAg positive), and 90.1% in mode Ⅱ (HBsAg, anti-HBc and anti-HBe positive) , No significant difference between the two (P> 0.05). Prompt that in the past that HBeAg into anti-HBe as replication of the virus stop, the indicators of remission is imprecise. From the serological point of view to determine the virus replication and contagious should proceed from the overall, not just based on a system.