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目的:比较鼻咽癌常规放疗和调强放疗的不良反应。方法:随机选择69例不同分期鼻咽癌患者,调强放疗组32例,常规放疗组37例。调强放疗组靶区为鼻咽肿瘤、咽旁间隙和颈部淋巴区,分次剂量为2.00～2.12Gy/次,33～35次;常规放疗组用面颈联合野照射DT 40～60Gy/(20～30次),耳前野补量至鼻咽区DT70Gy,颈部预防总量为DT 50～55Gy。结果:调强放疗组和常规放疗组口干发生率分别为9.38%(3/32)和94.59%(35/37),张口困难发生率分别为6.25%(2/32)和72.97%(27/37),2组比较均差异有统计学意义(均P<0.01)。结论:鼻咽癌调强放疗与常规放疗相比较,在提高肿瘤局部控制率的同时明显降低了不良反应的发生,在患者经济条件允许的情况下应首选调强放疗。
Objective: To compare the adverse reactions of conventional radiotherapy and intensity-modulated radiotherapy of nasopharyngeal carcinoma. Methods: A total of 69 NPC patients with different staging were randomly selected. Twenty-two patients received IMRT and 37 patients received conventional radiotherapy. The target volume of IMRT group was nasopharyngeal neoplasms, parapharyngeal space and lymphatic area of the neck. The doses were 2.00-2.12Gy / time and 33-35 times. The conventional radiotherapy group was treated with DT 40-60 Gy / (20 to 30 times), the amount of antebellum to the nasopharynx DT70Gy, the total amount of neck prevention DT 50 ~ 55Gy. Results: The incidence rates of dry mouth in ITA group and conventional radiotherapy group were 9.38% (3/32) and 94.59% (35/37), respectively. The incidence of mouth opening difficulty were 6.25% (2/32) and 72.97% / 37). There was significant difference between the two groups (all P <0.01). CONCLUSIONS: Compared with conventional radiotherapy, IMRT in nasopharyngeal carcinoma can significantly reduce the incidence of adverse reactions while improving local tumor control rate. IMRT should be the first choice in patients with economic conditions.