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目的:了解我院2008-2010年病原菌分布和细菌耐药变迁及抗菌药物应用情况,为临床应用抗菌药物提供参考。方法:回顾性分析我院2008-2010年住院患者病原菌耐药情况及抗菌药物的用药频度(DDDs)。结果:共分离出3185株病原菌,其中革兰阴性菌占55.63%、革兰阳性菌占27.40%、真菌占16.95%,革兰阳性菌和革兰阴性菌的检出率呈逐年上升趋势。以大肠埃希菌、凝固酶阴性葡萄球菌、肠球菌、肺炎克雷伯菌和铜绿假单胞菌最为常见。头孢菌素类、氟喹诺酮类和头霉素类药用量始终位于DDDs排序的前3位。结论:应严格执行《抗菌药物临床应用指导原则》,加强细菌耐药监测工作,根据病原菌种类及药敏试验结果选药。
OBJECTIVE: To understand the distribution of pathogens and the change of bacterial resistance in our hospital from 2008 to 2010 and the application of antibacterials, so as to provide a reference for the clinical application of antibacterials. Methods: The pathogenic bacteria resistance in hospitalized patients and the frequency of antimicrobial medication (DDDs) in our hospital from 2008 to 2010 were analyzed retrospectively. Results: A total of 3185 pathogens were isolated, of which Gram-negative bacteria accounted for 55.63%, Gram-positive bacteria accounted for 27.40%, fungi accounted for 16.95%, Gram-positive bacteria and Gram-negative bacteria showed a rising trend year by year. Escherichia coli, coagulase-negative staphylococcus, enterococci, Klebsiella pneumoniae and Pseudomonas aeruginosa most common. Cephalosporins, fluoroquinolones and cephamycins are always in the top three DDDs. Conclusion: The Guiding Principles of Clinical Application of Antibacterials should be strictly enforced to strengthen the monitoring of bacterial resistance. Drugs should be selected according to the types of pathogens and drug sensitivity test results.