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采用流式细胞检测技术对31例急性心肌梗塞患者发病后各期外周血B细胞、T细胞及其亚群进行连续定量检测,并分析检测数据与临床病程的关系。结果提示:1.急性心肌梗塞可造成患者机体免疫应答的明显变化。发病第1周及第2周时患者细胞免疫和体液免疫功能均出现严重的抑制及损害。2.急性心肌梗塞后机体免疫功能的明显变化与心肌细胞坏死后细胞内物质释放有关。3.研究急性心肌梗塞患者免疫功能改变有助于对患者周身病理生理变化做出全面评价。
Flow cytometry was used to detect the quantity of B cells, T cells and their subsets in peripheral blood of 31 patients with acute myocardial infarction at different stages after the onset of disease. The relationship between the data and clinical course was analyzed. The results suggest that: 1. Acute myocardial infarction can cause significant changes in the patient’s immune response. In the first week and the second week, the cellular immunity and humoral immunity of the patients all showed serious inhibition and damage. 2. After acute myocardial infarction significant changes in immune function and myocardial cell necrosis after the release of intracellular substances. Study of immune function changes in patients with acute myocardial infarction help to make a comprehensive evaluation of the pathophysiological changes in patients with whole body.