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目的探讨小剂量米力农对充血性心力衰竭患者心功能及肿瘤坏死因子、白介素-6的影响。方法将2010年7月-2011年7月25例心功能为Ⅲ～Ⅳ级的充血性心力衰竭患者给予小剂量米力农[0.5μg/(kg.min)]治疗5～7d,观察治疗前后患者的心功能(LVEF、FS、LVDD、E/A、BNP)和炎症因子(TNF-α、IL-6)的变化。结果显效8例,有效12例,无效5例,总有效率80%。同治疗前相比较,治疗后患者的LVDD、LVEF、FS、E/A及BNP指标有明显改善(P<0.05),TNF-α、IL-6指标有明显下降(P<0.05)。结论米力农治疗重度充血性心力衰竭,能够改善患者心脏收缩和舒张功能,降低了患者血清中TNF-α、IL-6水平,安全有效,值得临床广泛应用。
Objective To investigate the effect of low dose milrinone on cardiac function, tumor necrosis factor and interleukin-6 in patients with congestive heart failure. Methods From July 2010 to July 2011, 25 cases of congestive heart failure patients with grade Ⅲ ~ Ⅳ heart failure were treated with low dose Milrinone [0.5μg / (kg · min)] for 5 ~ 7 days. Before and after treatment The changes of cardiac function (LVEF, FS, LVDD, E / A, BNP) and inflammatory cytokines (TNF-α, IL-6) in patients were analyzed. The results were markedly effective in 8 cases, effective in 12 cases, ineffective in 5 cases, the total effective rate was 80%. Compared with those before treatment, LVDD, LVEF, FS, E / A and BNP were significantly improved (P <0.05) and TNF-α and IL-6 were significantly decreased after treatment (P <0.05). Conclusion Milrinone treatment of severe congestive heart failure, can improve cardiac systolic and diastolic function, reduce serum TNF-α, IL-6 levels, safe and effective, it is widely used in clinical.