伏格特-小柳-原田综合征(Vogt-Koyanagi-Harada Syndrome,VKH)是一种罕见的多系统性炎症性疾病,常累及皮肤、神经系统、眼及耳部,主要表现有皮肤白斑、脱发,神经刺激症状,双侧肉芽肿性虹膜炎、葡萄膜炎、渗出性视网膜剥离并可伴听力减退。病因尚不明确,可能是自身免疫异常的结果。临床上强调早期诊断及治疗,目前有效的药物是糖皮质激素,该病预后各异并且皮肤脱色素现象可长期存在。 Vogt-Koyanagi-Harada Syndrome Vogt-Koyanagi-Harada Syndrome (VKH) is a rare multi-systemic inflammatory disease, often involving the skin, nervous system, eyes and ears, the main manifestations of leukoplakia, hair loss , Neurological irritation, bilateral granulomatous iris, uveitis, exudative retinal detachment and may be associated with hearing loss. Etiology is not yet clear, may be the result of abnormal autoimmune. Clinical emphasis on early diagnosis and treatment, the current effective drug is glucocorticoid, the disease prognosis and skin depigmenting phenomenon can exist for a long time.