在1952年,局部应用氢化可的松取得了非常令人鼓舞的效果,而可的松则被证明为完全无效。从此以后许多新的糖皮质激素和各种制剂相继问世。局部应用糖皮质激素一般是有效的,但某些糖皮质激素则可通过局部皮肤吸收而作用于肾上腺垂体轴,故估价此作用对药物投放市场的安全性仍是必要 In 1952, the topical application of hydrocortisone achieved very encouraging results, while cortisone proved to be completely ineffective. Since then, many new glucocorticoids and various preparations have come out. Topical application of glucocorticoids is generally effective, but certain glucocorticoids act on the adrenal pituitary axis through local skin absorption, so evaluating this effect is still necessary for the safety of the drug on the market