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目的观察阿托伐他汀联合普罗布考治疗颈动脉粥样硬化斑块的临床疗效及对血脂水平的影响。方法将137例确诊颈动脉粥样硬化斑块形成的患者随机分为他汀组(62例)和联合治疗组(75例),他汀组采用阿托伐他汀治疗,联合组采用阿托伐他汀与普罗布考联合治疗,共观察6个月,比较两组治疗前后斑块面积情况及血脂变化。结果治疗6个月后,两组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)降低,高密度脂蛋白胆固醇(HDL-C)水平升高,颈动脉内膜斑块面积减少,差异有统计学意义;联合治疗组TC、TG与LDL-C变化与他汀组比较,差异有统计学意义(P<0.05)。结论阿托伐他汀联合普罗布考治疗能够明显改善颈动脉粥样硬化斑块,显著调节血脂水平。
Objective To observe the clinical efficacy of atorvastatin combined with probucol in the treatment of carotid atherosclerotic plaques and its effect on blood lipid levels. Methods A total of 137 patients with diagnosed carotid atherosclerosis plaque were randomly divided into statin group (n = 62) and combination therapy group (n = 75). Atorvastatin group was used in the statin group and atorvastatin group Probucol combined treatment, were observed for 6 months, comparing the two groups before and after treatment of plaque area and blood lipid changes. Results After 6 months of treatment, the levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL- The area of arterial intima plaque was decreased, the difference was statistically significant. The changes of TC, TG and LDL-C in combination therapy group were statistically different from those in statin group (P <0.05). Conclusion Atorvastatin combined with probucol can significantly improve carotid atherosclerotic plaque and significantly regulate blood lipid levels.