论文部分内容阅读
目的探讨应用叶酸、维生素B12治疗糖尿病合并脑梗死(DCI)患者,对其血浆同型半胱氨酸(Hcy)水平的影响,及其对认知功能恢复的疗效。方法将60例DCI患者,按双盲方法分成两组,DCI-A组予补充叶酸、维生素,DCI-B组则否,两组患者同时接受缺血性卒中常规治疗。于入院24h内及治疗后第3个月的最后1d,分别测定各组血浆Hcy水平,并用MMSE量表了解患者治疗前后认知功能的改变。结果叶酸、维生素B12治疗3个月后患者的血浆Hcy水平降低。DCI-A组MMSE评分的提高明显高于DCI-B组(P<0.05)。结论应用叶酸、维生素B12治疗3个月,可显著降低患者的Hcy水平,而且较常规治疗对改善患者的认知功能有更好的疗效。
Objective To investigate the effect of folic acid and vitamin B12 on plasma homocysteine (Hcy) level in patients with diabetes complicated with cerebral infarction (DCI) and its effect on the recovery of cognitive function. Methods Sixty patients with DCI were divided into two groups according to double-blind method. Folic acid, vitamin and DCI-B were given to DCI-A group. Both groups were given conventional treatment of ischemic stroke. The levels of Hcy in each group were measured at 24h after admission and at the last day of the third month after treatment. The changes of cognitive function in patients before and after treatment were measured by MMSE. Results Folic acid, vitamin B12 3 months after treatment in patients with plasma Hcy levels decreased. The MMSE score of DCI-A group was significantly higher than that of DCI-B group (P <0.05). Conclusion Treatment with folic acid and vitamin B12 for 3 months can significantly reduce the level of Hcy in patients and has a better therapeutic effect on improving cognitive function than conventional treatment.