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目的:观察丹参注射液联合厄贝沙坦氢氯噻嗪治疗难治性高血压的临床疗效。方法:将符合病例入选标准的120例难治性高血压患者随机分为观察组、对照组,每组60例。两组患者均嘱合理饮食,对照组治以厄贝沙坦氢氯噻嗪片,1次/d,1片/次。观察组在服用厄贝沙坦氢氯噻嗪片的基础上以丹参注射液20 mL+200 mL生理盐水静脉滴注,1次/d。2组均以治疗2周为1个疗程,治疗2个疗程后评价疗效。结果:显效率观察组76.67%,对照组53.33%,两组差异显著(P<0.05)。总有效率观察组93.33%,对照组73.33%,两组差异显著(P<0.05)。两组收缩压(SBP),舒张压(DBP)治疗后均明显下降(P<0.05),观察组改善优于对照组(P<0.05)。两组治疗后血清胱抑素(Cys C)、尿mALB,血肌酐(SCr),尿素氮(BUN)明显改善(P<0.05),观察组改善优于对照组(P<0.05)。两组不良反应发生率无统计学差异。结论:观察丹参注射液联合厄贝沙坦氢氯噻嗪治疗难治性高血压临床疗效显著,降压作用好,且可改善血清Cys C,尿mALB,SCr,BUN。
Objective: To observe the clinical efficacy of Danshen injection combined with irbesartan hydrochlorothiazide in the treatment of refractory hypertension. Methods: A total of 120 patients with refractory hypertension were enrolled in the observation group and control group, 60 cases in each group. Both groups were given a reasonable diet, the control group treated with irbesartan hydrochlorothiazide tablets, 1 / d, 1 / time. The observation group taking irbesartan hydrochlorothiazide tablets based on the Danshen injection 20 mL + 200 mL saline intravenously, 1 / d. 2 groups were treated for 2 weeks for a course of treatment, after 2 courses of treatment evaluation of efficacy. Results: The markedly effective rate was 76.67% in the observation group and 53.33% in the control group, with significant difference between the two groups (P <0.05). The total effective rate was 93.33% in the observation group and 73.33% in the control group, with significant difference between the two groups (P <0.05). The systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both groups were significantly decreased (P <0.05), and the improvement in the observation group was better than that in the control group (P <0.05). Serum levels of cystatin C, urine mALB, serum creatinine (SCr) and blood urea nitrogen (BUN) were significantly improved after treatment in both groups (P <0.05). The improvement in the observation group was better than that in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: The observation of Danshen injection combined with irbesartan hydrochlorothiazide treatment of refractory hypertension clinical efficacy, good antihypertensive effect, and can improve serum Cys C, urine mALB, SCr, BUN.