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目的：探讨在妊娠鼠中慢性抑制ＮＯ的合成，产生妊高征样症状。方法：妊娠鼠随机分为３组，于妊娠１４ｄ腹腔内连续注射生理盐水１ｍｌ（对照组）、亚硝基左旋精氨酸甲酯（Ｌ－ＮＡＭＥ）每只鼠每天３０ｍｇ（用药组）、Ｌ－ＮＡＭＥ每只鼠每天６０ｍｇ（双倍用药组）。记录收缩压、尿蛋白、血小板、胎仔重量及大小和胎盘重量及大小、畸形率及死亡率。结果：收缩压在用药组及双倍用药组与对照组比较有明显增加，尿蛋白在用药后与用药前比较明显增加，血小板用药组与对照组比较明显减少，胎仔的重量、大小及胎盘重量及大小，用药组及双倍用药组与对照组比较明显减少且畸形率和死亡率增加，有剂量依赖性。结论：慢性阻滞ＮＯ合成，可引起高血压、胎儿发育迟缓，出现尿蛋白、血小板减少。可提供与妊高征相似的动物模型。
OBJECTIVE: To investigate the chronic inhibition of NO synthesis in pregnant rats and to induce PIH-like symptoms. Methods: Pregnant mice were randomly divided into 3 groups: 1 ml of normal saline (control group), 30 mg of L-NAME (administration group), L -NAME Each mouse 60mg daily (double drug group). Systolic blood pressure, urinary protein, platelets, fetal weight and size, placental weight and size, deformity and mortality were recorded. Results: Compared with the control group, the systolic blood pressure increased obviously in the treatment group and the double-dosed group, and the urinary protein increased obviously after treatment. Compared with the control group, the urinary protein decreased significantly. The weight, size and weight of the placenta And size, medication group and double-drug treatment group was significantly reduced compared with the control group and the deformity rate and mortality increased in a dose-dependent manner. Conclusion: Chronic blockade of NO synthesis can cause high blood pressure, fetal retardation, urinary protein and thrombocytopenia. Can provide similar animal model of pregnancy-induced hypertension.