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目的:观察参茶白术散配合多潘立酮及单用多潘立酮2种方案治疗儿童功能性消化不良的效价比。方法:将165例功能性消化不良患者随机分为2组,治疗组85例用参茶白术散配合多潘立酮口服,对照组83例单口服多潘立酮,2周为1疗程。观察比较2组临床疗效及效果和成本差别。结果:治疗组85例中临床治愈45例,显效25例,有效13例,无效3例,临床治愈率52.9%;对照组83例中临床治愈19例,显效25例,有效29例,无效10例,临床治愈率22.9%。2组临床治愈率比较,差异有显著性意义(P<0.05)。从药物经济学角度分析,参苓白术散配合多潘立酮(治疗)组产生单位效益费用较单用多潘立酮(观察)组少15.8元。结论:参苓白术散配合多潘立酮治疗功能性消化不良的方案效价比良好,经济安全,可供临床医生优先选择。
OBJECTIVE: To observe the potency-value ratio of Shencha Baizhu San combined with domperidone and domperidone alone in treating children with functional dyspepsia. Methods: One hundred and sixty-five patients with functional dyspepsia were randomly divided into two groups. The treatment group (85 cases) was treated with Ganshu Baizhu Powder combined with domperidone orally. The control group (83 cases) took domperidone orally once for two weeks for one course of treatment. Observation and comparison of two groups of clinical efficacy and effectiveness and cost differences. Results: Among the 85 cases in the treatment group, 45 cases were clinically cured, 25 cases were markedly effective, 13 cases were effective, 3 cases were ineffective, and the clinical cure rate was 52.9%. In the control group, 19 cases were clinically cured, 25 cases were markedly effective, 29 were effective, For example, the clinical cure rate of 22.9%. There was significant difference between two groups in clinical cure rate (P <0.05). From the perspective of pharmacoeconomics, Shenling Baizhu San combined with domperidone (treatment) group had a unit benefit cost of 15.8 yuan less than that of domperidone alone group. Conclusion: Shenling Baizhu San combined with domperidone treatment of functional dyspepsia program cost-effective, economic security, available to clinicians preferred.