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目的:探讨5-氨基酮戊酸光动力疗法(5-ALA-PDT)联合祛疣洗剂治疗肛周尖锐湿疣的疗效和安全性。方法:将66例患者随机分为2组各33例,治疗组应用CO2激光祛除疣体后,联合光动力疗法及祛疣洗剂治疗;对照组应用CO_2激光祛除疣体后联合祛疣洗剂外洗治疗,分别在第1、2、3月末观察患者的复发情况及不良反应。结果:治疗组治愈率和复发率分别为81.8%、18.2%,对照组分别为54.6%、45.5%,2组比较,差异均有统计学意义(P<0.05)。2组患者均未出现严重不良反应,耐受良好。结论:光动力联合祛疣洗剂治疗肛周尖锐湿疣临床疗效显著、复发率低,且无严重不良反应。
Objective: To investigate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) in combination with Quyu lotion in the treatment of perianal condyloma acuminatum. Methods: Sixty-six patients were randomly divided into two groups (n = 33). The treatment group was treated with CO2 laser to eliminate the wart, and combined with photodynamic therapy and Quxu decoction. The control group was treated with CO_2 laser to eliminate the wart, External wash treatment, respectively, in 1, 2, 3, observe the patient’s recurrence and adverse reactions. Results: The cure rate and recurrence rate were 81.8% and 18.2% in the treatment group and 54.6% and 45.5% in the control group respectively. There was significant difference between the two groups (P <0.05). No serious adverse reactions occurred in both groups, which were well tolerated. Conclusion: The combination of photodynamic therapy and Qutu decoction for the treatment of perianal condyloma acuminatum has significant curative effect, low recurrence rate and no serious adverse reactions.