许多临床医生认为,大多数单纯性尿路感染(UTIs)应该用大剂量药物长期治疗。可是,无确切证据表明长疗程比短疗程更有效。 早期研究 Gruneberg和Brumfitt用2克周效磺胺单剂量治疗25例菌尿症的妇女,治愈22例。这种“超长时作用”磺胺和0.5克/8小时氨苄青霉素连用7天的效果一样。作者给12例怀孕三个月无菌尿症的妇女100毫克单剂量呋喃妥因。治愈6例。这6例放射学显示尿路无异常。但其余6例感染病人,3例放射学显示有病变—肾结石、肾盂输尿管连接处阻塞和单侧回流肾病。Williams和Smith用4种不同方案单剂量联合治疗妊娠期间有菌尿的妇女,其中最成功的是单剂量联用链霉素(1克)和2—磺胺—3—甲氧吡嗪(2克),在受治的47例妇女中获得77％的治愈率。但认为妊娠期使用链霉素可能危险。 Many clinicians believe that most simple urinary tract infections (UTIs) should be treated with high doses of drugs for long-term treatment. However, there is no conclusive evidence that long courses are more effective than short courses. Earlier studies of Gruneberg and Brumfitt treated 25 patients with bacteriuria with a single dose of 2 g of the potent sulfamethoxazole and were cured in 22 patients. The effect of this “long-acting” sulfa and 0.5 gram / 8-hour ampicillin for 7 days is the same. The authors gave 100 mg single dose nitrofurantoin to 12 pregnant women with three months of aphthous urinary tract disease. Six cases were cured. These 6 radiographs showed no abnormalities in the urinary tract. However, the remaining 6 patients were infected, and 3 radiographs showed lesions - nephrolithiasis, pyeloureteral obstruction and unilateral reflux nephropathy. Williams and Smith treated four women with bacteriuria during pregnancy with four different single-dose regimens. The most successful of these were single-dose streptomycin (1 g) and 2-sulfa-3-methoxypyrazine ), A cure rate of 77% was achieved in 47 women treated. But that the use of streptomycin during pregnancy may be dangerous.