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目的:检测胰腺癌患者血浆溶血磷脂酸(lysphosphaticlic acid,LPA)的水平,评价LPA在胰腺癌诊治中的临床意义。方法:采用定磷法检测2006年6月至2010年10月南京第一医院收治的胰腺癌患者50例、胰腺良性疾病患者32例及健康志愿者36人的血浆LPA水平,同时测定血清CA19-9、AFP和CEA的水平;免疫组化法检测胰腺癌组织及癌旁胰腺组织LPA2受体的表达。分析血浆LPA水平与胰腺癌临床病理特征的关系。结果:胰腺癌患者血浆LPA水平明显高于胰腺良性疾病患者和健康志愿者[(4.10±2.03)vs(3.28±1.26)、(2.27±1.02)μmol/L,P<0.05],胰腺癌患者血浆LPA水平和血清CA19-9水平密切相关(r=0.9070,P<0.01)。胰腺癌组织LPA2受体表达阳性率显著高于癌旁正常胰腺组织(88%vs 4%,P<0.05)。血浆LPA水平的升高与胰腺癌浸润和淋巴结转移等相关。结论:血浆LPA检测为胰腺癌诊断和预后判断增加了一项潜在的评价指标。
Objective: To detect the level of plasma lysophosphaticlic acid (LPA) in patients with pancreatic cancer and evaluate the clinical significance of LPA in the diagnosis and treatment of pancreatic cancer. Methods: The plasma LPA levels in 50 patients with pancreatic cancer, 32 patients with benign pancreatic diseases and 36 healthy volunteers admitted to the First Hospital of Nanjing from June 2006 to October 2010 were determined by the method of determining phosphorus. Plasma levels of CA19- 9, AFP and CEA, and the expression of LPA2 receptor in pancreatic cancer tissues and adjacent pancreatic tissues by immunohistochemistry. The relationship between plasma LPA level and clinicopathological features of pancreatic cancer was analyzed. Results: Plasma LPA levels in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic diseases and healthy volunteers [(4.10 ± 2.03 vs 3.28 ± 1.26, 2.27 ± 1.02 μmol / L, P <0.05] LPA levels and serum CA19-9 levels are closely related (r = 0.9070, P <0.01). The positive rate of LPA2 receptor expression in pancreatic cancer tissues was significantly higher than that in adjacent normal pancreatic tissues (88% vs 4%, P <0.05). Plasma LPA levels and pancreatic cancer invasion and lymph node metastasis and other related. Conclusion: LPA plasma test for the diagnosis and prognosis of pancreatic cancer added a potential evaluation index.