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mn 6A修饰是真核生物中最常见、最丰富的修饰形式之一，在不改变碱基序列的情况下对基因的转录后表达水平发挥调控作用。该修饰过程是动态可逆的，由甲基转移酶、去甲基化酶和相应的读取蛋白协同调控，参与mn 6A修饰的酶出现异常会导致肿瘤等一系列疾病的发生。本文综述了mn 6A修饰相关蛋白的组成与功能，以及mn 6A修饰在肿瘤增殖、侵袭与转移、血管生成、炎症反应、免疫反应、基因组不稳定、细胞代谢中的功能和调节机制。n “,”N6-methyladenosine(mn 6A)modification is one of the most common and abundant modification form in eukaryotes, and it can regulate the post-transcriptional expression levels of genes without changing the base sequences.The modification process is dynamic and reversible and is coordinately regulated by methyltransferases, demethylases and corresponding reader proteins.Abnormality of enzymes for mn 6A modificationcan cause a series of diseases, such as tumors.This article reviews the composition and functions of mn 6A modification-related proteins, and the functions and regulatory mechanisms of mn 6A modification in the processes of tumor proliferation, invasion and metastasis, angiogenesis, inflammatory response, immune response, genomic instability, and cell metabolism.n