12 November 2018? 2018 Huazhong University of Science and TechnologyThe duodenum is a unique location for primary squamous cell carcinoma (SCC). Although this tumor was first reported in 1940 in the English language literature [1], there is still little information on this subject with very few articles and case reports. So far, fewer than 10 cases of primary SCC of the duodenum have been reported. Here, we present a case of a 45-year-old male with primary pure SCC of the duodenum.