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随着自由基生物学的发展,从分子水平揭示了自由基在很多疾病机理中的重要作用。超氧化物歧化酶(SOD)是需氧生物体内的一种内生性氧自由基清除剂,其含量及活性可间接反应体内氧自由基存在的水平。本文检测112例消化道疾病血清SOD的含量,以探讨消化道疾病患者SOD含量变化的意义,并间接了解氧自由基与胃肠道粘膜损害之间的关系。 1 资料与方法 1.1 临床资料:经内镜与病理确诊的112例消化道疾病,其中消化性溃疡伴出血33例(球部溃疡26例,胃溃疡7例),年龄20～73岁,平均36.5岁;
With the development of free radical biology, the important role of free radicals in many disease mechanisms has been revealed at the molecular level. Superoxide dismutase (SOD) is an endogenous oxygen radical scavenger in aerobic organisms. Its content and activity indirectly reflect the level of oxygen free radicals in the body. In this paper, the detection of serum SOD in 112 cases of gastrointestinal diseases in order to explore the significance of SOD content changes in patients with digestive diseases, and indirectly understand the relationship between oxygen free radicals and gastrointestinal mucosal damage. 1 Materials and Methods 1.1 Clinical data: 112 cases of gastrointestinal diseases confirmed by endoscopy and pathology, including peptic ulcer with hemorrhage in 33 cases (26 cases of ulceration, gastric ulcer in 7 cases), aged 20 to 73 years, an average of 36.5 year old;