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目的 观察结直肠癌病人血清Ⅳ型胶原 (ColⅣ )及层粘连蛋白 (LN)的含量变化并探讨其意义。方法 选择结直肠癌病人 51例作观察组 (其中 4 1例行根治术 ) ,32例非肿瘤手术病人作对照组 ,采用放射免疫法测定ColⅣ和LN。结果 观察组ColⅣ和LN的含量明显高于对照组(P <0 0 1) ,其中DukesB期及C期明显高于A期 (P <0 0 1) ,根治术后ColⅣ及LN较术前下降 (P<0 0 5)。结论 ColⅣ及LN与结直肠癌的浸润转移相关 ,检测其含量有助于判断病情和预后。
Objective To observe the changes of serum type IV collagen (Col IV) and laminin (LN) in patients with colorectal cancer and discuss its significance. Methods A total of 51 patients with colorectal cancer were enrolled in the observation group (including 41 patients undergoing radical surgery) and 32 non-cancer patients were used as the control group. ColIV and LN were measured by radioimmunoassay. Results The contents of Col IV and LN in the observation group were significantly higher than those in the control group (P <0 01). The Dukes B and C stages were significantly higher than those in the A stage (P <0 01). Coliv and LN decreased after the operation compared with preoperative. (P<0 0 5). Conclusion ColIV and LN are associated with the invasion and metastasis of colorectal cancer. The detection of ColIV and LN is helpful to determine the condition and prognosis.