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目的 了解我国健康青年人一过性下食管括约肌松弛(TLESR)与酸反流的关系及脂肪含量不同的饮食对健康人TLESR和酸反流的影响。方法 采用下食管括约肌(LES)袖套式测压管、单晶锑pH 测定管,同步记录10 名志愿者空腹1 小时及餐后4 小时内的LES压力和食管pH 值。结果 酸反流均发生在LES压力低于2m m Hg 时,其中90.4% 发生在TLESR时。餐后酸反流显著增加( P< 0.01),TLESR及TLESR伴酸反流率也显著增加(P均< 0.01)。低脂餐与高脂餐对酸反流、TLESR及TLESR伴酸反流率的影响差异无显著性意义( P均> 0.05)。结论 TLESR是健康人酸反流发生的主要机制,健康人餐后酸反流增加主要是因为TLESR及TLESR伴酸反流增加。高脂餐并不增加健康人的TLESR及酸反流
Objective To investigate the relationship between transient lower esophageal sphincter relaxation (TLESR) and acid reflux in healthy young people and the effects of diet with different fat content on TLESR and acid reflux in healthy subjects. Methods The LES pressure and esophageal pH value of 10 volunteers were measured simultaneously by LES cuff pressure tube and single crystal antimony pH measuring tube simultaneously in one volunteer for 1 hour and 4 hours after the meal. Results Acid reflux occurred at LES pressures below 2 m Hg, of which 90.4% occurred at TLESR. Postprandial acid reflux was significantly increased (P <0.01), TLESR and TLESR acid reflux rate was also significantly increased (P all <0.01). Low-fat meal and high-fat meal on acid reflux, TLESR and TLESR acid reflux rate was no significant difference (P all> 0.05). Conclusion TLESR is the main mechanism of acid reflux in healthy people. The increase of postprandial acid reflux in healthy people is mainly due to the increase of reflux of acid with TLESR and TLESR. High-fat meals do not increase TLESR and acid reflux in healthy people