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目的:总结乳腺小管癌(TC)的相关研究,分析其临床病理学特征、诊断及鉴别诊断要点,探讨其预后相关因素和治疗方法的进展。方法:应用计算机检索PubMed及CNKI期刊全文数据系统,以“乳腺癌”和“小管癌”为关键词,检索1995-2010年相关文献共1025篇,纳入标准:1)TC的临床病理学特征、诊断及鉴别诊断、治疗方法和预后研究。2)TC的大样本病例(>30例)回顾性研究。排除≤10例的病例报道和重复性研究类文章,根据纳入标准符合分析的文献24篇。结果:小管癌具有较低的恶性程度,较早的临床和病理分期,良好的免疫组织化学结果,预后良好。保留乳房手术可以取得良好的治疗效果。结论:TC是一类恶性程度较低的非特殊浸润性乳腺癌,具有较好的生物学行为特性和较好的预后,保留乳房手术是其治疗的有效方式和发展方向。
OBJECTIVE: To summarize the related research of breast ductal carcinoma (TC), analyze its clinicopathological features, diagnosis and differential diagnosis points, and to explore the prognosis related factors and the progress of treatment methods. Methods: The PubMed and CNKI journals full-text data system were searched by computer. The key words of “breast cancer” and “small duct carcinoma” were searched. A total of 1025 articles were retrieved from 1995 to 2010 and included in the following criteria: 1) Pathological features, diagnosis and differential diagnosis, treatment and prognosis. 2) A large sample of TC (> 30 cases) was retrospectively studied. Cases of ≤10 cases and repetitive researches were excluded, and 24 articles were analyzed according to the inclusion criteria. Results: Tubular cancer has a lower degree of malignancy, early clinical and pathological staging, good immunohistochemical results, the prognosis is good. Breast conserving surgery can achieve good therapeutic effect. Conclusion: TC is a kind of non-specific invasive breast cancer with low malignant degree. It has good biological behavior and good prognosis. To keep breast surgery is an effective way and direction of its treatment.