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众所周知,人参皂甙具有多种生理作用,近年来对人参皂甙抗癌活性的研究受到了广泛重视,为了探讨人参皂甙结构与活性之间的构效关系,往往需要进行人参皂甙的半合成及结构修饰工作。在上述工作中常用的酸水解法得不到真正的甙元,只是次级甙元。前已报道,人参皂甙在碱水解条件下,其甙元的结构不变化,为了探索出最佳的碱水解条件,作者用均匀设计法进行了考察,结果较为满意。
As we all know, ginsenosides have various physiological functions. In recent years, the research on the anticancer activity of ginsenosides has received extensive attention. In order to investigate the structure-activity relationship between the structure and activity of ginsenosides, semisynthesis and modification of ginsenosides are often required. jobs. The acid hydrolysis method commonly used in the above work does not obtain a real one, only a secondary one. It has been reported previously that the structure of the aglycons of ginsenosides under alkaline hydrolysis conditions does not change. In order to explore the best alkali hydrolysis conditions, the authors conducted a uniform design method and found satisfactory results.