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目的研究1999～2003年我院真菌性角膜炎的病原学分布。方法回顾性分析我院化脓性角膜炎真菌涂片标本922份、连续性真菌培养标本1814份,并与我院1975～1986、1989～1997年两个阶段比较。结果涂片标本阳性率为27%(306/922),与培养的阳性一致率为82%;真菌培养阳性率为25%(456/1814);上半年与下半年的比例为1:2.2;培养阳性的真菌菌株中,镰孢菌属占34%(155/456),曲霉菌属占26%(118/456);茄病镰孢菌和烟曲霉菌分别是最主要的致病菌株;与我院前两个阶段的资料比较曲霉菌的比例有明显下降而镰孢菌有明显上升的趋势;另外,456份标本中80份伴有细菌培养阳性。结论目前,镰孢菌属和曲霉菌属是广州地区真菌性角膜炎的主要致病真菌。
Objective To study the etiological distribution of fungal keratitis in our hospital from 1999 to 2003. Methods Retrospective analysis of 922 fungal smear specimens of hospital suppurative keratitis, 1814 copies of continuous fungal culture specimens, and with our hospital from 1975 to 1986, 1989 to 1997 two stages compared. Results The positive rate of smear specimens was 27% (306/922). The positive rate of smear specimens was 82%. The positive rate of fungi culture was 25% (456/1814). The ratio of the first half to the second half was 1: 2.2. Fusarium species accounted for 34% (155/456) and Aspergillus species (26%) (118/456). Fusarium solani and Aspergillus fumigatus were the main pathogenic strains, respectively. As compared with the data of the first two stages of our hospital, the percentage of Aspergillus decreased significantly while that of Fusarium increased significantly. In addition, 80 of 456 specimens were positive for bacterial culture. Conclusions Fusarium and Aspergillus are the main pathogenic fungi of fungal keratitis in Guangzhou.