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目的研究糖尿病对大鼠局部脑缺血再灌注损伤后血脑屏障通透性的影响。方法雄性SD大鼠120只,随机分为脑缺血组和糖尿病伴脑缺血组,每组60只大鼠。糖尿病模型用链脲佐菌素腹腔内注射制备,用线栓法制作局灶性脑缺血模型。观察各组大鼠神经行为学缺陷;分别用TTC染色法和伊文思蓝注射法检测大鼠脑梗死体积及BBB破坏的程度。结果糖尿病伴脑缺血组大鼠脑梗死体积及BBB开放程度均明显大于其他各组(P<0.05),神经功能损伤也较其他各组明显。结论糖尿病可引起血脑屏障通透性增加,可作为糖尿病对微血管损伤的一个敏感性指标。
Objective To investigate the effect of diabetes on the permeability of the blood-brain barrier after focal cerebral ischemia-reperfusion injury in rats. Methods 120 male Sprague-Dawley rats were randomly divided into cerebral ischemia group and diabetic cerebral ischemic group with 60 rats in each group. The diabetic model was made by intraperitoneal injection of streptozotocin, and focal cerebral ischemia model was made by thread method. The neurobehavioral deficits of the rats in each group were observed. The extent of infarct volume and BBB damage were detected by TTC staining and Evans blue injection respectively. Results The volume of cerebral infarction and the degree of openness of BBB in diabetes mellitus with cerebral ischemia group were significantly higher than those in other groups (P <0.05), and the neurological impairment was more obvious than other groups. Conclusion Diabetes mellitus can cause the increase of blood-brain barrier permeability, which can be used as a sensitive indicator of microvascular injury in diabetes mellitus.