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1983年Suginra首创在超声引导下经皮肝穿瘤内注射无水酒精治疗小肝癌,临床效果满意。我所于1989年4月至1994年4月应用此法治疗肝癌188例,共1429人次,至今未发现有严重副反应发生及癌延针道转移现象。现就注射无水酒精治疗肝癌的有关问题综述如下。 1 治疗机理在超声引导下无水酒精可准确注入肿瘤内直接杀伤癌细胞,无水酒精使肿瘤组织脱水固定,肿瘤细胞蛋白质凝固、变性、坏死,肿瘤血管局部内皮细胞破坏,可形成血栓,切断血供,导致癌细胞死亡和纤维化,肿瘤因而可缩小或不再增大。动物实验证实,在0.2cm×0.4cm的大鼠肝癌内注入无水酒精0.5ml,3日后肿瘤可有70%发生凝固坏死,注入0.3ml,肝脏平均坏死
In 1983, Suginra first initiated ultrasound-guided percutaneous intrahepatic injection of absolute alcohol for the treatment of small hepatocellular carcinoma with satisfactory clinical results. In our hospital from April 1989 to April 1994, this method was used to treat 188 cases of liver cancer, a total of 1429 person-times. No serious side effects and cancerous canal approach have been found so far. The following is a summary of the issues related to the treatment of liver cancer by injection of absolute alcohol. 1 Therapeutic mechanism Ultrasound-guided anhydrous alcohol can be injected directly into the tumor to directly kill the cancer cells. The anhydrous alcohol causes dehydration and fixation of the tumor tissue. The tumor cell protein coagulates, degenerates, and necroses. The tumor vascular local endothelial cells are destroyed and can form thrombosis. Blood supply leads to death and fibrosis of the cancer cells, and the tumor can thus shrink or no longer grow. Animal experiments confirmed that 0.5 ml of absolute alcohol was injected into 0.2 cm x 0.4 cm rat hepatic carcinoma. After 3 days, tumors were 70% coagulated and necrotic, 0.3 ml injected, and the average liver necrosis.